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Figure 3.32 A digital tele-microscopic system. (A, left): Image acquisition workstation: automatic microscope (1), CCD camera (2), video monitor (3), computer with an A/D converter attached to the CCD, image memory, and a database to manage the patient image le (4), the video monitor (3) showing a captured image from the microscope being digitized and shown on the workstation monitor (5). (A, right) Remote diagnostic workstation (6). Thumb nail images at the bottom of both workstations are the images sent to the diagnostic workstation (7) from the acquisition workstation (7). (B) Closeup of the acquisition workstation. Pertinent data related to the exam are shown in various windows. Icons on the bottom right (8) are six simple click-and-play functions: transmit, display, exit, patient information, video capture, digitize, and store. Six images had been captured and stored shown in the lower icons. The last captured image (9) is displayed on the workstation monitor. (Prototype telemicroscopic imaging system at the Laboratory for Radiological Informatic Lab, UCSF. Courtesy of Drs. S. Atwater, T. Hamill, and H. Sanchez [images], and Nikon Res. Corp. and Mitra Imag. Inc. [equipment])

Figure 16-11

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involved in supporting pregnancy. As soon as a woman becomes pregnant, the site on the ovary from which the ovum was shed is transformed into a corpus luteum. That structure then becomes an abundant source of progesterone. The resulting high serum levels of hormone help maintain the uterus and not incidentally prevent ovulation. Progesterone supplements would thus, at least in theory, be useful in treating various malfunctions of the reproductive cycle. Progesterone itself, however, must be given by injection, as the drug is not active by the oral route. A considerable amount of research thus went into the search for derivatives that could be given by mouth. This account to some extent departs from strict chronology here as the estrogen-derived progestins discussed further on came rst. Research in various laboratories established that the presence of additional substituents at the 6 and 17 positions increased potency and oral activity. The drugs that came out of these programs all incorporate a hydroxyl group at the 17 position on the ve-membered D ring as its ester with acetic acid. The rst of these drugs, medroxyprogesterone acetate,17 which acquired the trade name Proveraw, was prepared by chemists at Upjohn (Fig. 10). The compound incorporates a methyl group at the 6 position. Addition of yet another carbon, this as a group connected to the 16 position in the D ring by a double bond, gives the progestin melengestrol acetate.18 Removal of two hydrogens from ring B in medroxyprogesterone acetate to give a double bond leads to megestrol acetate19; replacement of the methyl

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Of course, if the covariance matrix of the observations is not described by (5.274), the ordinary least squares estimator is linear in the observations and unbiased but it is not best.

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